A high-fat diet does not influence the growth of the Dunning R3327-H transplantable prostate adenocarcinoma
Schwab, E.D.; Normolle, D.; Pacis, R.A.; Cho, S.S.; Pienta, K.J.
Anticancer Research 18(5a): 3603-3607
1998
ISSN/ISBN: 0250-7005 PMID: 9858946 Document Number: 490195
Background: The etiology of prostate cancer is currently a mystery. Several epidemiological studies suggest a link between dietary fat and prostate cancer. In vitro and in vivo studies support this evidence. Using the Dunning model of rat prostate cancer we hypothesized that a high-fat diet (20%) would increase the growth of the R3327-H tumor. Materials and Methods: R3327-H tumors were unplanted subcutaneously into male Copenhagen rats which were fed diets with 5 or 20% total fat. Tumors were allowed to grow for 16 weeks; they were then excised and weighed. The initial and final weights of the rats were also recorded. Results: Statistical analysis revealed the level of dietary fat was a positive predictor of weight gain (p < 0.01). So effect on tumor growth was seen when compared to dietary fat, fiber type, or the interaction of fat and fiber. Discussion: Growth of the R3327-H tumor, when implanted subcutaneously, is not affected by the level of dietary fat.