Omega-3 fatty acids inhibiting the growth of a transplantable rat mammary adenocarcinoma
Kort, W.J.; Weijma, I.M.; Bijma, A.M.; van Schalkwijk, W.P.; Vergroesen, A.J.; Westbroek, D.L.
Journal of the National Cancer Institute 79(3): 593-599
1987
ISSN/ISBN: 0027-8874 PMID: 3476794 Document Number: 294808
BN/Bi inbred female rats fed diets containing different amounts of polyunsaturated fatty acids, either of the omega-3 or omega-6 type, each received an implant of a syngeneic mammary adenocarcinoma. When the diameter of the tumors reached 20 mm, they were surgically removed; 2 weeks thereafter the animals were sacrificed and lung metastases were counted. Cellular immune response was determined before tumor inoculation; certain prostaglandin values in plasma and platelet aggregation were measured before and after tumor inoculation. Plasma prostaglandin E2 and thromboxane B2 values were significantly decreased in those rats fed a diet containing menhaden oil. 6-Keto-prostaglandin F1 alpha, cellular immune response, and platelet function were not significantly different in either one of the diet groups. Tumor growth in the groups of rats receiving the omega-3 fatty acids in their diet was significantly inhibited in comparison with that in the rats receiving the omega-6 fatty acids. However, the number of metastases was not significantly altered.