Top Abstract Purchase Related
Home
>
Node
>
Subnode

Synthesis and anti-influenza virus-A activity of circular dumbbell RNA DNA chimeric oligonucleotides

Abe, T.; Hatta, T.; Yamakawa, H.; Takai, K.; Yokota, T.; Takaku, H.

Nucleic Acids Symposium Series 37: 219-220

1997

ISSN/ISBN: 0261-3166
PMID: 9586078
Document Number: 470072
We have designed a new type of antisense oligonucleotide, containing two hairpin loop structures with RNA/DNA base pairs (sense (RNA) and antisense (DNA)) in the double helical stem (nicked and circular dumbbell DNA/RNA chimeric oligonucleotides). The reaction of the nicked and circular dumbbell DNA/RNA chimeric oligonucleotides with RNase H gave the corresponding anti-DNA together with the sense RNA cleavage products. These oligonucleotides were more resistant to exonuclease attack. We also describe the anti-Fluv activities of circular dumbbell DNA/RNA chimeric oligonucleotides.

Document emailed within 1 workday
Secure & encrypted payments

Nishimura, T.; Toku, H.; Yamazaki, C.; Hasegawa, K.; Sakaguchi, H.; Nagaki, D. 1975: Antiviral compounds. IX. Synthesis and anti-influenza virus activity of bis-amidinohydrazones of glyoxal and methylglyoxal Kitasato Archives of Experimental Medicine 48(4): 171-181
Nishimura, T.; Toku, H.; Yamazaki, C.; Hasegawa, K.; Nagaki, D. 1977: Antiviral compounds. XI. Synthesis and anti-influenza virus activity of alkoxy-phenyl- and styryl-glyoxal bis-amidinohydrazones Kitasato Archives of Experimental Medicine 50(1-2): 31-38
Chomik, M. 1986: Ultrastructure and some biological properties of influenza A virus. I. Alterations in the activity of surface antigens of influenza A virus by enzymes and infectious activity of such changed viruses Archivum Immunologiae et Therapiae Experimentalis 34(1): 49-57
Reĭzin, F.N.; Chumakov, M.P.; Mart'ianova, L.I. 1982: Stabilization of the influenza virus by normal serum. Increase in the infectious activity of the influenza virus in chick embryos Voprosy Virusologii 27(5): 106-109
Zhenodarova, S.M.; Khabarova, M.I. 1980: Stepwise synthesis of oligonucleotides. XXVIII. Synthetic activity of S-protein Molekuliarnaia Biologiia 14(2): 299-315
Rasool, A.; Khan, M.-U.-R.; Ali, M.A.; Anjum, A.A.; Ahmed, I.; Aslam, A.; Mustafa, G.; Masood, S.; Ali, M.A.; Nawaz, M. 2017: Anti-avian influenza virus H9N2 activity of aqueous extracts of Zingiber officinalis (Ginger) and Allium sativum (Garlic) in chick embryos Pakistan Journal of Pharmaceutical Sciences 30(4): 1341-1344
Smirnov, V.S.; Garshinina, A.V.; Shtro, A.A.; Anikin, V.B.; Galochkina, A.V.; Beliavskaia, S.V.; Zarubaev, V.V. 2014: Anti-viral activity of a complex of the glycyrrhizic acid-alpha-glutamyltryptophan against the experimental lethal influenza infection in white mice caused by the oseltamivir-resistant strain of the virus Voprosy Virusologii 59(5): 31-38
Amvros'eva, T.V.; Itkin, Z.B.; Sklianskaia, E.I. 1983: Synthesis of virus-specific proteins in a mixed infection caused by various strains of influenza virus a and B Voprosy Virusologii 28(4): 90-96
Zarubaev, V.V.; Garshinina, A.V.; Kalinina, N.A.; Shtro, A.A.; Beliaevskaia, S.V.; Nebol'sin, V.E.; Kiselev, O.I. 2010: Protective activity of Ingavirin in experimental lethal influenza due to pandemic influenza virus a (H1N1)v in albino mice Antibiotiki i Khimioterapiia 55(5-6): 24-31
Isaeva, E.I.; Rovnova, Z.I.; Poliakova, T.G.; Viazov, S.O. 1993: The incidence of detecting influenza virus antigens in the peripheral blood lymphocytes of donors in relation to the epidemic activity of influenza viruses a and B Voprosy Virusologii 38(4): 146-149
Varich, N.L. 1989: The mechanism of RNA synthesis in the influenza virus Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 8: 3-13
Chimirri, A.; Grasso, S.; Montforte, A.M.; Monforte, P.; Zappalà, M. 1994: Anti-HIV agents. III. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]imidazo[4,5-b]pyridines Farmaco 49(5): 345-348
Chimirri, A.; Grasso, S.; Monforte, A.M.; Monforte, P.; Rao, A.; Zappalà, M.; Bruno, G.; Nicolò, F.; Scopelliti, R. 1997: Anti-HIV agents. V. Synthesis, structure and in vitro anti-HIV activity of novel 1H,3H-naphtho[2',3':4,5]imidazo[1,2-c]thiazoles Farmaco 52(11): 673-677
Tian, S.L.; Zhao, S.W.; Zhu, A.T.; Fang, Y.; Li, K.Q. 1993: Studies on anti-tumor agents. I: Synthesis and anti-cancer activity of amino acid derivatives of norcantharidin Yao Xue Xue Bao 28(11): 870-875
Vu, H.; Singh, P.; Joyce, N.; Hogan, M.E.; Jayaraman, K. 1993: Synthesis of cholesteryl supports and phosphoramidites containing a novel peptidyl linker for automated synthesis of triple-helix forming oligonucleotides (TFOs) Nucleic Acids Symposium Series 29: 19-20
Kawashima, E.; Sekine, T.; Miyahara, M.; Aoyama, Y.; Hirao, I.; Kainosho, M.; Kyogoku, Y.; Ishido, Y. 1992: Highly stereoselective synthesis of (2'R)-[2'-2H]-deoxyribonucleosides and synthesis of their oligonucleotides Nucleic Acids Symposium Series 27: 81-82
Toyoda, T. 2003: Target of developing the new anti-influenza virus reagents Nihon Rinsho. Japanese Journal of Clinical Medicine 61(11): 1980-1986
Sugaya, N. 2006: Treatment of influenza virus infection with anti-virals Nihon Rinsho. Japanese Journal of Clinical Medicine 64(10): 1840-1844
Isaeva, E.I.; Platonova, A.L.; Rovnova, Z.I.; Kosiakov, P.N. 1979: Influenza virus neuraminidase and its role in anti-influenzal immunity Voprosy Virusologii 1979(6): 615-619
Higashihara, M.; Igarashi, Y.; Saito, Y. 1976: Recombinant influenza-virus vaccines. IV. Segregation of antigenic and some biological properties of Influenza virus neuraminidase by recombination Kitasato Archives of Experimental Medicine 49(3): 81-91