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Highly stereoselective synthesis of (2'R) -[2'-2H]-deoxyribonucleosides and synthesis of their oligonucleotides

Kawashima, E.; Sekine, T.; Miyahara, M.; Aoyama, Y.; Hirao, I.; Kainosho, M.; Kyogoku, Y.; Ishido, Y.

Nucleic Acids Symposium Series 27: 81-82

1992

ISSN/ISBN: 0261-3166
PMID: 1289834
Document Number: 392837
Highly stereoselective synthesis of (2'R)-[2'-2H]-2'-deoxyribonucleosides (2'R:2'S = > 99:1) were accomplished by treating 2'-bromo-3',5'-O-TPDS-2'-deoxyribonucleosides with tributyltin deuteride at lower temperatures such as -60 degrees C in the presence of triethylborane. Moreover, synthesis of some oligodeoxyribonucleosides involving them will be described.

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