Synthesis of novel fluorescent 9,10-bisphenylethynylanthracene-derived pseudonucleoside and its introduction into oligonucleotides

Malakhov, A.D.; Prokhorenko, I.A.; Kuznetsova, S.V.; Skorobogatyĭ, M.V.; Korshun, V.A.; Berlin, I.A.

Bioorganicheskaia Khimiia 25(12): 933-937

1999


ISSN/ISBN: 0132-3423
PMID: 10734554
Document Number: 505993
The functionalization of the fluorescent hydrocarbon 9,10-bisphenylethynylanthracene to afford its dihydroxybutyl derivative was developed. Based on this pseudonucleoside, the phosphoramidite and a solid-phase carrier were obtained and used for the preparation of oligonucleotides containing a new fluorescent label for biopolymers.

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