Synthesis of oligonucleotides carrying linker groups at 1'-position of sugar residues
Ono, A.; Dan, A.; Matsuda, A.
Nucleic Acids Symposium Series 29: 13-14
1993
ISSN/ISBN: 0261-3166 PMID: 8247737 Document Number: 410199
A novel 2'-deoxyuridine analogue carrying an aminobutyl linker at 1'-position of the sugar residue was synthesized and incorporated into oligonucleotides, then an anthraquinone derivative was attached to the amino group. The oligonucleotides carrying the linker groups were more resistant to nuclease P1 and venom phosphodiesterase than an unmodified oligonucleotide.
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