Protective activity of Ingavirin in experimental lethal influenza due to pandemic influenza virus a (H1N1) v in albino mice
Zarubaev, V.V.; Garshinina, A.V.; Kalinina, N.A.; Shtro, A.A.; Beliaevskaia, S.V.; Nebol'sin, V.E.; Kiselev, O.I.
Antibiotiki i Khimioterapiia 55(5-6): 24-31
2010
ISSN/ISBN: 0235-2990 PMID: 21033471 Document Number: 639753
Despite obvious success in the vaccine development and chemotherapy of influenza, it remains a poorly controlled infection leading to emergence of new pandemic variants of the virus with high morbidity and mortality. We investigated the protective activity of Ingavirin against the lethal influenza A (H1N1) 2009 virus infection on albino mice. Oral use of Ingavirin resulted in sharp decreasing of the mortality (index of protection up to 57%), slight decreasing of the infectious titer of the virus in the lungs (up to 40-fold), normalizing of the body weight dynamics and the lung tissue structure vs. the placebo-treated control. The degree of the bronchial epithelium damage was also strongly decreased. The results allow to consider Ingavirin as an effective antiviral against the current pandemic influenza virus.