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Synthesis of virus-specific proteins in a mixed infection caused by various strains of influenza virus a and B

Amvros'eva, T.V.; Itkin, Z.B.; Sklianskaia, E.I.

Voprosy Virusologii 28(4): 90-96

1983

ISSN/ISBN: 0507-4088
PMID: 6636702
Document Number: 201332
Mixed infection produced by different strains of influenza virus was studied. Both laboratory and epidemic strains as well as attenuated vaccine strains were used. Simultaneous double infection of MDCK cells with different combinations of influenza A and B strains led to manifested interference accompanied by phenotypic mixing. In the cells infected with influenza A and B viruses the major virus-specific proteins of both types were found, their rate of synthesis was, however, decreased as compared to that in the course of single infection. The inhibition was reciprocal and differentiated: the synthesis of NP and HA proteins was inhibited stronger than that of NS 1 protein. Homotypic double infection with influenza A strains also led to a decrease in virus-specific protein synthesis. The analysis of virus progeny revealed phenotypic mixing of HA or complete inhibition of formation of virions carrying one of the hemagglutinin types (e.g. type A hemagglutinin in heterotypic double infection). The extent of interference and phenotypic mixing depended on the multiplicity of infection.

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