Synthesis of virus-specific RNA under conditions of homologous and heterologous interference by Newcastle disease virus
Zhdanova, L.V.; Mamontova, T.V.
Voprosy Virusologii 1976(4): 425-429
1976
ISSN/ISBN: 0507-4088 PMID: 188251 Document Number: 108888
Homologous and heterologous interference by Newcastle disease virus (NDV) was manifested in a marked inhibition of virus-specific RNA synthesis of both the interacting viruses. Inactivation of the interfering NDV by irradiation reduced its capacity to inhibit the synthesis of virus-specific RNA of the homologous virus, leaving its effect on the synthesis of RNA of the heterologous virus unchanged. In contrast, treatment of cell cultures with heparin leading to reduced interferon production eliminated the heterologous interference but did not affect the homologous interference.