Sendai virus multiplication in the presence of ceruloplasmin and homologous virus envelopes
Tomas, E.; Samuel, I.; Cajal, N.
Acta Virologica 23(3): 221-225
1979
ISSN/ISBN: 0001-723X PMID: 41434 Document Number: 151649
Pre-incubation of Sendai virus with ceruloplasmin induced in chorioallantoic membrane (CAM) fragments the synthesis of a population with decreased infectivity and high hemagglutinating (HA) and neuraminidase (NA) activities. Pre-incubation with solubilized virus envelopes led to the production of a viral population with the same infectivity as the control but with lower HA and NA activities. Pre-incubation of the virus with a mixture of ceruloplasmin and solubilized envelopes depressed the overall virus synthesis; the resulting population had a low infectivity and high HA and NA activities. The variation in the HA/NA ratio indicates a modification in the envelope structure.