Inhibitors of lipid peroxidation among new pyrimido[1',6':1,2]pyrido[3,4-b]indoles
Domány, G.; Gere, A.; Paróczai, M.; Szántay, C.; Ferenczy, G.G.; Schön, I.; Kiss, B.; Kárpáti, E.
Die Pharmazie 49(11): 807-810
1994
ISSN/ISBN: 0031-7144 PMID: 7838865 Document Number: 434993
A series of potent inhibitors of NADPH- and Fe(2+)-dependent lipid peroxidation has been found among new pyrimido[1'6':1,2]pyrido[3,4-b]indole derivatives. According to preliminary structure-activity relationship analysis the saturated pyrimidine moiety was responsible for this effect. Some members of this family were effective in a bilateral carotid occlusion model in mice, and some derivatives showed protective effect in a mouse head injury model.