Dietary nucleotides: effects on the gastrointestinal system in swine
Bustamante, S.A.; Sanches, N.; Crosier, J.; Miranda, D.; Colombo, G.; Miller, M.J.
Journal of Nutrition 124(1 Suppl): 149s-156s
1994
ISSN/ISBN: 0022-3166 PMID: 8283306 Document Number: 433265
Nucleotides in the intestinal lumen may decrease the inflammatory response to ischemia-reperfusion. In a newborn-swine model, we showed that perfusion of the intestinal lumen with nucleotides in concentrations similar to those in human milk induced hyperemia. The levels of hypoxanthine (and xanthine) were not increased in the presence of nucleotides during ischemia-reperfusion, and the number of leukocytes ac-cumulated in the intestine was reduced in the presence of nucleotides. Furthermore, nucleotides may have decreased protein leak and the production of nitric oxide during ischemia. These effects are not changed significantly in the presence of an adenosine antagonist. We interpreted our results to indicate that the protective effects of nucleotides in the intestinal lumen are not due to adenosine alone.