Dietary calcium and fluoride interactions in swine: in utero and neonatal effects
Forsyth, D.M.; Pond, W.G.; Krook, L.
Journal of Nutrition 102(12): 1639-1646
1972
ISSN/ISBN: 0022-3166 PMID: 4634996 Document Number: 56771
Piglets at birth and at 4 weeks of age from successive litters and successive generations from dams given diets low, 0.5 and 0.4%, or high, 1.2 and 1.0%, in Ca and P, respectively, without or with 150 or 450 mg F/kg were studied for physical and chemical changes in bone and for histological changes in bone and soft tissues. In the bones of baby pigs at birth, there was no "generation build-up", or increase of F concentration in the first compared with the second litter. Increase in F concentration was a linear function of the amount of F in the diet of the sow, and was influenced by the amounts of Ca and P in the diet. Increased Ca and P decreased accumulation of F in offspring with large amounts of F, producing a Ca-P amount X F interaction in pigs both at birth and 4 weeks of age. Humerus density of pigs at birth was influenced nonlinearly by F; intermediate amounts of F decreased density, but the highest did not. Decreased length, width, volume and fresh weight of the humerus of baby pigs from sows given additional F indicated a depression of skeletal growth of foetuses caused by F; this depression persisted in pigs 4 weeks old. Neither Ca-P amount nor amount of F in the diet of the sow influenced Ca or P concentrations of the bone of offspring or caused any pathological change in soft tissues studied.