Calcium metabolism and mineralocorticoid-induced hypertension: effects of parathormone and exogenous thyrocalcitonin and of variations in dietary calcium and magnesium
Berthelot, A.; Miss-Pages, C.; Gairard, A.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 171(5): 1101-1106
1977
ISSN/ISBN: 0037-9026 PMID: 146554 Document Number: 119720
Male Sprague-Dawley rats were parathyroidectomized (PTX) or thyroparathyroidectomized (TPTX) and a week later had 2 pellets with 25 mg deoxycorticosterone acetate implanted in the thoracic region. They had a balanced diet and 0.9% NaCl solution to drink. PTX rats were given 10 u USP parathyrin daily for 14 days and 20 u USP thereafter or were untreated. TPTX rats were given 15 u USP parathyrin and 12 mMRC calcitonin daily or were untreated. Every second day the rats were given 3 mu g thyroxine to maintain bodyweight at that of controls. Arterial pressure of untreated PTX and TPTX fell but in those given parathyrin or parathyrin and calcitonin it remained similar to that of intact controls. Blood Ca was decreased in untreated PTX and TPTX rats but treatment with the hormones increased Ca to normal. Rats given a solution of 0.9% CaCl2 or 0.9% MgCl2 to drink had significantly lower arterial pressure than controls.