Alterations of membrane fluidity in K562 cells exposed to the anticancer drug adriamycin
Marutaka, M.; Iwagaki, H.; Suguri, T.; Tanaka, N.; Orita, K.
Research Communications in Molecular Pathology and Pharmacology 85(2): 163-170
1994
ISSN/ISBN: 1078-0297 PMID: 7994561 Document Number: 428510
The incubation of K562 cells with adriamycin resulted in a decrease in cell membrane fluidity as measured by electron spin resonance using the paramagnetic probe 5-doxylstearic acid. Coincidently, the antiproliferative effect of adriamycin was progressively inhibited as the concentration of adriamycin was increased. The results indicate that adriamycin induces changes in the plasma membrane of K562 cells after exposure to a low level of this agent.
Document emailed within 1 workday
Related Documents
Sugiyama, M.; Sakanashi, T.; Okamoto, K.; Chinami, M.; Hidaka, T.; Ogura, R. 1986: Membrane fluidity in Ehrlich ascites tumor cells treated with adriamycin Biotechnology and Applied Biochemistry 8(2-3): 217-221Martinova, Y.S.; Nikolova, D.B. 1990: Ultrastructural alterations in mouse spermatogenic cells after treatment with anticancer drug biocarbazine Zeitschrift für Mikroskopisch-Anatomische Forschung 104(6): 969-974
Marsh, W.; Center, M.S. 1987: Adriamycin resistance in HL60 cells and accompanying modification of a surface membrane protein contained in drug-sensitive cells Cancer Research 47(19): 5080-5086
Jóźwiak, Z.; Schön, W.; Kraft, G.; Gärtner, H. 1992: Fluidity alterations induced by chemical modification of erythrocyte membrane proteins Biochemistry International 28(2): 265-272
1975: Doxorubicin (Adriamycin)--a new anticancer drug Medical Letter on Drugs and Therapeutics 17(10): 42-43
Fry, D.W.; Jackson, R.C. 1986: Membrane transport alterations as a mechanism of resistance to anticancer agents Cancer Surveys 5(1): 47-79
Iwagaki, H.; Fuchimoto, S.; Miyake, M.; Orita, K. 1988: Monitoring of the effect of anticancer drugs on the membrane potential and cytoplasmic free calcium ion mobilization in cancer cells as a drug sensitivity test Gan to Kagaku Ryoho. Cancer and ChemoTherapy 15(9): 2725-2730
Hoshino, M.; Koyama, Y.; Sugano, K.; Kanno, M.; Satou, N.; Abe, R. 1989: Enhanced effect of hepatic arterial infused anticancer drugs on rabbit VX-2 carcinoma by means of combination with Lipiodol. Adriamycin versus Lipiodol adriamycin sandwich method and adriamycin suspended in a Lipiodol Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(8 Part 2): 2810-2813
Iwagaki, H.; Marutaka, M.; Nezu, M.; Suguri, T.; Tanaka, N.; Orita, K. 1994: Cell membrane fluidity in K562 cells and its relation to receptor expression Research Communications in Molecular Pathology and Pharmacology 85(2): 141-149
Ding, H.; Peng, R.; Chen, J. 1998: Effects of high dietary zinc on liver function, hepatic drug metabolism enzymes and membrane fluidity in mice Wei Sheng Yan Jiu 27(3): 180-182
Sakanashi, T.; Sugiyama, M.; Suematsu, T.; Hidaka, T.; Ogura, R. 1986: Delayed alteration of membrane fluidity in intact cultured B-16 melanoma cells affected by ultraviolet irradiation Biochemistry International 12(2): 341-346
Winocour, P.D.; Watala, C.; Perry, D.W.; Kinlough-Rathbone, R.L. 1992: Decreased platelet membrane fluidity due to glycation or acetylation of membrane proteins Thrombosis and Haemostasis 68(5): 577-582
Rendu, F.; Marche, P.; Viret, J.; Daveloose, D.; Leterrier, F.; Levy-Toledano, S.; Caen, J.P. 1985: Molecular membrane organization in normal and pathological platelets: changes in inositide metabolism and membrane fluidity Nouvelle Revue Francaise d'Hematologie 27(4): 293-297
Berkow, R.L.; Weisman, S.J.; Tzeng, D.; Haak, R.A.; Kleinhans, F.W.; Barefoot, S.; Baehner, R.L. 1984: Comparative responses of human polymorphonuclear leukocytes obtained by counterflow centrifugal elutriation and Ficoll-Hypaque density centrifugation. II. Membrane potential changes, membrane receptor analysis, membrane fluidity, and analysis of the effects of the preparative techniques Journal of Laboratory and Clinical Medicine 104(5): 698-710
Hamada, H.; Okochi, E.; Watanabe, M.; Oh-hara, T.; Sugimoto, Y.; Kawabata, H.; Tsuruo, T. 1988: Mr 85,000 membrane protein specifically expressed in adriamycin-resistant human tumor cells Cancer Research 48(24 Part 1): 7082-7087
White, J.F.; Carlson, G.P. 1979: Influence of alterations in drug metabolism on spontaneous and epinephrine-induced cardiac arrhythmias in animals exposed to trichloroethylene Toxicology and Applied Pharmacology 47(3): 515-527
Allegrezza-Giulietti, A.; Serretti, R.; Beccerica, E.; Ferretti, G.; Cervini, C. 1991: Beta-thromboglobulin and polymorphonuclear leukocytes activation. (Effects on chemiluminescence, release of membrane bound calcium, NADPH-oxidase activity and membrane fluidity) Biochemistry International 24(2): 273-279
Suzuki, M.; Kawaguchi, Y.; Momose, M.; Morita, T.; Yokoyama, K.; Miyahara, T. 1988: 1,25-Dihydroxyvitamin D stimulates sodium-dependent phosphate transport by renal outer cortical brush-border membrane vesicles by directly affecting membrane fluidity Biochemical and Biophysical Research Communications 150(3): 1193-1198
Yawata, Y. 1983: Recent progress in research on red cell membrane disorders in Japan: pathogenesis of microspherocytosis in hereditary spherocytosis, sodium transport abnormalities in stomatocytosis, and homeo-adaptive compensatory mechanism for membrane fluidity in red cell membrane lipid abnormalities Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 46(7): 1426-1440
Guan, Z.; Wang, S.; Li, Y.; Yang, Y. 2000: Kinetics of plasma membrane and mitochondrial alterations in HL-60 cells undergoing apoptosis Wei Sheng Yan Jiu 29(2): 83-86