Ultrastructural alterations in mouse spermatogenic cells after treatment with anticancer drug biocarbazine
Martinova, Y.S.; Nikolova, D.B.
Zeitschrift für Mikroskopisch-Anatomische Forschung 104(6): 969-974
1990
ISSN/ISBN: 0044-3107 PMID: 2096537 Document Number: 364140
Single doses of anticancer drug biocarbazin (BC) - DTIC synonym - were injected intraperitoneally at 50 and 200 mg/kg body weight to sexually mature BALB/c mice. Among other features previously reported (Martinova et al. 1989) BC causes ultrastructural alterations in spermatogonia and spermatocytes significantly expressed after administration of higher dose. In addition BC induces some defects in acrosome formation of early spermatids in Golgy and cap phase, while spermatids in later stages of maturation showed marked resistance to BC treatment.