Absolute and relative bioavailability of germanium in the rabbit
Anger, F.S.; Anger, J.P.; Sado, P.A.; Chevanne, F.
Journal de Pharmacie de Belgique 49(5): 395-401
1994
ISSN/ISBN: 0047-2166 PMID: 7837032 Document Number: 428511
The debated consumption of germanium suggested the authors to compare biopharmaceutical parameters of germanium oxide and germanium sesquioxide. A first evaluation, in rabbit, has been based on Germanium blood levels determined by atomic absorption spectrometry, after cross administration of both products by the I.V. and oral routes. When given orally, the apparent oxide bioavailability is very low (about 10%) but better than that of the sesquioxide. That difference could result from differences of disposition parameters of both products, which have to be studied late.