Absolute and Relative Bioavailability of Glutaron--A new Derivative of Glutamic Acid
Smirnova, L.A.; Ryabukha, A.F.; Kuznetsov, K.A.; Suchkov, E.A.; Perfilova, V.N.; Tyurenkov, I.N.
Eksperimental'naia i Klinicheskaia Farmakologiia 78(12): 23-25
2015
ISSN/ISBN: 0869-2092 PMID: 27051924 Document Number: 681888
The pharmacokinetics of studies of 3-phenylglutamic acid hydrochloride (glutaron) has been studied in rats. The main pharmacokinetic parameters show low values of the half-life (T1/2 = 3.75 h), mean retention time in the body (MRT = 5.77 h). The medium rate of drug concentration decrease in the blood plasma leads to a low value of the area under pharmacokinetic curve (AUC = 41.18 mg · h/mL). The general volume of distribution (Vd = 3.42 L/kg) is 3.5 times greater than the volume of extracellular fluid in the rat body. These data indicate a high ability of the glutaron to be distributed and accumulated in animal tissues. The value of absolute bioavailability is 84%, and the relative bioavailabity is 100%.