Pharmacokinetics and absolute bioavailability of intramuscular tranexamic acid in man
Puigdellívol, E.; Carral, M.E.; Moreno, J.; Plà-Delfina, J.M.; Jané, F.
International Journal of Clinical Pharmacology Therapy and Toxicology 23(6): 298-301
1985
ISSN/ISBN: 0174-4879 PMID: 4018929 Document Number: 492
The bioavailability of tranexamic acid after the administration of a single intramuscular dose was estimated in three healthy male volunteers. 500 mg tranexamic acid were given intramuscularly and intravenously, as a bolus injection, to each subject on separate occasions. Following intramuscular administration, the peak plasma concentrations were attained after approximately one hour and the apparent elimination half-life was about two hours. The absolute bioavailability was 105.2 +/- 10.7% (mean +/- SD). At the dose given, the bioavailability of tranexamic acid after intramuscular administration is fast and complete.
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