Pharmacokinetic consequences of long term coadministration of cimetidine and triazolobenzodiazepines, alprazolam and triazolam, in healthy subjects
Pourbaix, S.; Desager, J.P.; Hulhoven, R.; Smith, R.B.; Harvengt, C.
International Journal of Clinical Pharmacology Therapy and Toxicology 23(8): 447-451
1985
ISSN/ISBN: 0174-4879 PMID: 2864320 Document Number: 491
The influence of administration of cimetidine (1 g daily for 2 wk) on the pharmacokinetics of alprazolam (0.5 mg t.i.d. instead of t.i.d.). For triazolam, used as a hypnotic drug, such dosage reduction appears unsuitable if administered on a once-nightly basis.
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