The effect of long-term use of cimetidine on the ultrastructure of gastric parietal cells in man
Pillay, C.V.; Moshal, M.G.; Booyens, J.
South African Medical Journal 55(24): 992-993
1979
ISSN/ISBN: 0256-9574 PMID: 472952 Document Number: 147089
The effect of long-term cimetidine therapy on the ultrastructure of human parietal cells was investigated in 2 subjects. It was found that after cimetidine therapy for 1 year: (i) the ultrastructural appearance of the parietal cells was normal, and (ii) the parietal cells responded normally to stimulation by pentagastrin. Evidence in favour of a membrane flow mechanism involved in acid secretion is presented.