Effects of high dietary zinc on liver function, hepatic drug metabolism enzymes and membrane fluidity in mice
Ding, H.; Peng, R.; Chen, J.
Wei Sheng Yan Jiu 27(3): 180-182
1998
ISSN/ISBN: 1000-8020 PMID: 10684126 Document Number: 487474
Mice were fed with high zinc diet (15 g/kg) for 3 weeks. High zinc could cause liver toxicity: 1. inhibiting the activity of GOT and GPT in liver homogenate, reducing GSH and glycogen contents. 2. increasing the activity of aniline hydroxylase and inhibiting the activities of NADPH-cytochrome C reducease, benzo-phytamine-N-demethylase and glutathione S-transferase. The activities of cytochrome P450 and cytochrome b5 were not obviously changed 3. increasing microsomal membrane fluidity in the superficial layers, but not in the deep layers.