Effect of intraventricular hemorrhage in newborns on levels of certain prostanoids in blood plasma
Szczapa, J.; Kornacka, M.; Rychlik, K.
Ginekologia Polska 64(4): 174-178
1993
ISSN/ISBN: 0017-0011 PMID: 8282238 Document Number: 417185
Recent studies suggest that eicosanoids might be involved in pathogenesis of vascular problems in preterm infants. The aim of the study was determine the concentrations most potent occurring vasoactive substances: Thromboxane A2 (TxA2) promoting vasoconstriction and prostacyclin (PGI2) causing vasodilation of vascular smooth muscles. We assessed the concentrations of stable metabolites TxA2-TxB2 and PGI2-6 keto PGF1 alpha in blood plasma by RIA method. It was found that neonates with RDS + IVH had significantly elevated TxB2 and 6 keto PGF1 alpha compared to healthy newborns, with transient tachypnoea and with RDS. High concentrations of thromboxane and prostacyclin metabolites in newborns plasma with IVH suggest a causative role of eicosanoids in pathogenesis of haemorrhage. The cells of impaired blood vessels may be probable source of these eicosanoids.