The effect of micronized phenofibrate on the lipoproteins of the blood plasma at different initial lipid levels
Perova, N.V.; Ozerova, I.N.; Kalinina, A.M.; Pavlova, L.I.; Olfer'ev, A.M.; Mel'kina, O.E.; Golubev, M.A.; Oganov, R.G.
Terapevticheskii Arkhiv 68(1): 71-76
1996
ISSN/ISBN: 0040-3660 PMID: 8644040 Document Number: 458243
Novel antihyperlipidemic micronized phenofibrate lipantil 200 M was tested for safety and efficacy (one 200 mg capsule a day for 3 months) in 27 patients having cholesterol level above 6.5 mmol/l. The effect emerged upon 1 month of administration and persisted till the end of the treatment. In combined hyperlipidemia triglycerides decreased by 45-60%, total cholesterol and LDL cholesterol by 10-12%. In isolated hyperlipidemia the latter two values appeared lower by 20-23 and 22-27%, respectively. After lipantil 200 M treatment HDL cholesterol went up by 9% in low baseline level (< 1 mmol/l) by 27%. No negative clinico-biochemical shifts were seen, while fibrinogen and uric acid reduced by 16%, apoB by 23-30%. Lipantil 200 M proved active against hyperlipidemia and is recommended for clinical practice.