The effect of new synthetic prostanoids on the indices of the blood coagulation system
Petrukhina, G.N.; Makarov, V.A.; Freĭmanis, I.F.; Lozha, E.V.; Sirotenko, A.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 58(5): 37-40
1995
ISSN/ISBN: 0869-2092 PMID: 8704588 Document Number: 445832
In the experiments on rabbits it was shown, that the administration of prostanoids IOS 3933 caused a reduction of ADP- and collagen induced platelet aggregation, platelet adhesion to collagen and elevation of t-PA level. This prostanoid prevented both a decrease in platelet count and reduction of AT III activity, but did not affect the protein C level during thromboplastin infusion.