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Effect of tri-iodine-containing x-ray contrast substances on the blood coagulation system in an experiment

Druzhinina, O.I.; Sergeev, P.V.; Byshevskiĭ, A.S.; Chabanov, M.K.

Farmakologiia i Toksikologiia 47(4): 63-65

1984

ISSN/ISBN: 0014-8318
PMID: 6479314
Document Number: 236210
Experiments on white rats were made to examine the time course of hemocoagulation changes induced by intravenous injection of the triiodine-containing radiographic contrast agents, bilignost, verografin, triombrast, iodamide-380. The substances were found to exert a biphasic action: an initial decrease in the total coagulation is replaced by a tendency toward hypercoagulemia. In experiments in vitro, the radiographic contrast agents increased the time of plasma recalcification, the prothrombin time and retarded the thrombin-fibrinogen and thrombin-plasma reactions. Bilignost produced the most marked hypocoagulemia. It is suggested that the direct effects of the drugs on blood coagulation involve a decrease in the total blood coagulation activity.

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