Progestational agents and blood coagulation. VIII. Effect of low-dose, alternate-day, estrogen-progestin combinations on blood coagulation factors in man, with a special note on the effect of freezing of blood samples
Ambrus, J.L.; Courey, N.G.; Browne, B.J.; Mink, I.B.; Moore, R.H.; Ambrus, C.M.
American Journal of Obstetrics and Gynecology 128(2): 161-166
1977
ISSN/ISBN: 0002-9378 PMID: 857675 Document Number: 110414
The effect of combined, low-dose oral contraceptives on blood coagulation factors was studied in 60 healthy women. 20 women received .5 mg/day norethindrone plus .06 mg ethinyl estradiol on alternate days of the cycle from Days 5 through 25, another group of 20 received an IUD, and a 3rd group of 20 received .5 mg/day norethindrone plus .045 mg ethinyl estradiol on alternate days of the cycle from Days 5 through 25. Blood samples were taken before and after 3 months of treatment. No clinically significant (P greater than .05) effect of either treatment regimen on such blood coagulation factors as platelet count, platelet adhesiveness, prothrombin time, thrombin time, fibrinogen, Factor 2 assay, Factors 5, 7, 8, 9, and 10, and fibrin/fibrinogen degradation products could be established. Both fresh and frozen blood samples were used in the study.