Activation of the antihemophilic globulin a (factor VIII) . 2. Effect of ampholine on the course of blood coagulation and the molecular conformation of factor VIIi
Liebe, S.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 37(4): 110-116
1982
ISSN/ISBN: 0044-2542 PMID: 6805144 Document Number: 192135
Ampholine leads to an increase of activity of factor VIII and in vitro at the same time inhibits the activation of factor XII. The influence on factor XII takes place via influence on the contact surface. All the other coagulation factors remain uninfluenced. There are no differences between normal plasma and plasma of haemophilia with regard to the influence by ampholine. The molecular weight of factor VIII remains uninfluenced by ampholine. The activity of the various molecular forms of factor VIII is increased at the same level by ampholine.