Platelet adhesiveness and aggregation in combined factor V and factor VIIi deficiency and in combined factor VIi and factor VIIi deficiency
Girolami, A.; de Marco, L.; Fabris, F.; Casonato, A.
Folia Haematologica 104(5): 663-669
1977
ISSN/ISBN: 0323-4347 PMID: 75135 Document Number: 114970
Platelet aggregation and adhesiveness were studied in 3 patients with combined factor V and factor VIII deficiency and in 3 patients with combined factor VII and factor VIII deficiency. The first three patients belonged to three different kindreds whereas the second group belonged to the same kindred. Serotonin C14 uptake and release was also found to be normal in these patients. These studies indicate that platelet function is normal in combined defects of factor VIII. These findings were in agreement with the presence of a normal bleeding time and a normal factor VIII antigen level in all these patients.