Effect of alpha- or beta-adrenergic antagonists on catecholamine-induced changes in the glucose and insulin levels of the blood plasma of swine
Brenner, K.V.; Gürtler, H.; Müller, I.
Archiv für Experimentelle Veterinarmedizin 36(5): 721-727
1982
ISSN/ISBN: 0003-9055 PMID: 6762173 Document Number: 189911
Each of four Pietrain and four Duroc X Landrace crossbred pigs were injected rapidly i/v with epinephrine (80 mu g/kg) or isoprenaline (55 mu g/kg), accompanied by slow i/v injection (45 min) of 1 ml/min NaCl, or of 2 mu g/kg/min of phentolamine or propranolol, after a priming injection of 100 mu g/kg of these anti-adrenergic agents. Distinct hyperglycaemia, induced by epinephrine, was significantly depressed by the alpha-adrenergic blocker, phentolamine, but only slightly stimulated by the beta-adrenergic blocker propranolol. Though epinephrine had only slight, transient effect on blood insulin values, isoprenaline caused some glycaemia, and considerably increased insulinaemia. Neither phentolamine nor propranolol had much effect on this insulin response to isoprenaline. No significant differences between the Pietrain and cross-bred pigs were observed.