The efficacy of hepatoprotectors and cytochrome P-450 inducers in correcting the functional activity of the hepatocyte microsomal system in an acute lesion of the liver in prepuberty
Khakimov, Z.Z.; Rakhmanov, A.K.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(4): 16-17
1992
ISSN/ISBN: 0869-2092 PMID: 1458177 Document Number: 403274
Intragastric CCl4 inhibited the activity of and lowered the levels of the major components of the hepatic monoohygenase enzyme system in one-month rats. Benzonal was found to be more effective in correcting the impaired monooxygenase enzyme system of hepatic cells in immature rats with acute hepatitis than silibor, phytin and zyxorin.
Document emailed within 1 workday
Related Documents
Gordienko, A.D. 1992: The effect of hepatoprotectors on the functional activity of rat hepatocyte mitochondria in in-vitro and in-vivo systems Eksperimental'naia i Klinicheskaia Farmakologiia 55(4): 18-19Demidenko, N.M.; Kamarin, A.S.; Silant'eva, E.A. 1990: Effect of the pesticide tocuthion on the activity of microsomal cytochrome P-450-dependent monooxygenases in the rat liver Gigiena Truda i Professional'nye Zabolevaniya (1): 45-46
Subkhankulova, T.N.; Liakhovich, V.V.; Vaĭner, L.M. 1987: Effect of the lipophilic spin-labeled inhibitor of cytochrome P-450 on the activity of the microsomal system Biokhimiia 52(7): 1186-1191
Ozaki, S. 1974: Effect of lipids on liver microsomal membranes. (1) Studies of a relationship between delipidation of liver microsomes with the various organic solvents and cytochrome c reductase activity linked to reduced nicotinamide adenine dinucleotide Hokkaido Journal of Medical Science 49(4): 326-336
Tatematsu, M.; Nakanishi, K.; Murasaki, G.; Miyata, Y.; Hirose, M.; Ito, N. 1979: Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats Journal of the National Cancer Institute 63(6): 1411-1416
Muna, W.F.; Smuckler, E.A. 1976: In vitro cytochrome b5 binding to microsomal membranes: functional and non-functional levels Research Communications in Chemical Pathology and Pharmacology 14(2): 287-294
Mal'tseva, I.K.; Zhirnov, G.F.; Dubovaia, T.K. 1987: Evaluation of the functional state of the hepatocyte monooxygenase system in rats with damaged innervation of the liver Biulleten' Eksperimental'noi Biologii i Meditsiny 103(4): 491-492
Khakimov, Z.Z.; Krakovskiĭ, M.E. 1990: The correction of disorders in the microsomal oxidation system of the liver in experimental acute liver failure Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1990(1): 21-23
Kuz'mitskiĭ, B.B.; Dad'kov, I.G.; Mashkovich, A.E.; Stoma, O.V.; Slepneva, L.M. 1990: Immunomodulators with an 8-azasteroid structure as inducers of liver cytochrome P-450 Farmakologiia i Toksikologiia 53(2): 52-55
Riabinin, V.E.; Lifshits, R.I. 1986: Functional activity of liver microsomes and the state of the lipid peroxidation system during acute burn toxemia Voprosy Meditsinskoi Khimii 32(3): 115-118
Antonova, G.N.; Khalilov, E.M.; Bachmanova, G.I.; Karuzina, I.I.; Skotselias, E.D. 1984: Change in the activity of the microsomal system of liver oxidation in rabbits in experimental atherosclerosis Voprosy Meditsinskoi Khimii 30(2): 67-71
Ahmed, R.S.; Pawar, S.S. 1997: Effect of inducers on hepatic microsomal mixed function oxidase system of male rats during food restriction Indian Journal of Experimental Biology 35(1): 46-49
Morgan, E.T.; Norman, C.A. 1990: Pretranslational suppression of cytochrome P-450h (IIC11) gene expression in rat liver after administration of interferon inducers Drug Metabolism and Disposition: the Biological Fate of Chemicals 18(5): 649-653
Shiohara, E.; Tsukada, M.; Chiba, S.; Yamazaki, H.; Nishiguchi, K.; Nakanishi, S. 1986: Effect of acute acetaldehyde inhalation on rat liver microsomal mixed function oxidase system Arukoru Kenkyu to Yakubutsu Izon 21(3): 216-223
McCallum, G.P.; Weedon, A.C.; Krug, P.; Bend, J.R. 1996: Microsomal cytochrome P450 peroxygenase metabolism of arachidonic acid in guinea pig liver Journal of Pharmacology and Experimental Therapeutics 278(3): 1188-1194
Kamiński, M.; Plewka, A.; Plewka, D.; Gaździk, T.; Czechowicz, K.; Urbańska, D. 1986: Effect of N-ethyl-N-nitrosourea on the liver ultrastructure. I. Activity of the cytochrome P-450-dependent hepatic monooxygenase system Medycyna Pracy 37(1): 12-21
Clement, B.; Jung, F.; Pfunder, H. 1993: N-hydroxylation of benzamidine to benzamidoxime by a reconstituted cytochrome P-450 oxidase system from rabbit liver: involvement of cytochrome P-450 IIC3 Molecular Pharmacology 43(3): 335-342
Valoti, M.; Costanzo, M.; Sgaragli, G.P.; Perez, V.; Fernandez-Alvarez, E.; Unzeta, M. 1994: Interactions of monoamine oxidase inhibitors, N-acetylenic analogues of tryptamine, with rat liver microsomal cytochrome P450 Journal of Pharmacy and Pharmacology 46(5): 360-365
Dieter, H.H.; Abel, J.; Ohnesorge, F.K. 1979: Additional induction of microsomal cytochrome(s) P 450 in mouse liver by consecutive application of cadmium chloride and phenobarbital Research Communications in Chemical Pathology and Pharmacology 24(2): 377-388
Senjo, M. 1985: Isolation and characterization of heme transfer protein involved in biosynthesis of microsomal cytochrome b5 from rat liver cytosol Hokkaido Journal of Medical Science 60(5): 625-634