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The correction of disorders in the microsomal oxidation system of the liver in experimental acute liver failure

Khakimov, Z.Z.; Krakovskiĭ, M.E.

Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1990(1): 21-23

1990

ISSN/ISBN: 0031-2991
PMID: 2352774
Document Number: 356361
The effect of inductors and hepatic protectors on the detoxification function of the liver was studied in male rats with acute renal insufficiency (ARI). All the agents which were studied (phenobarbital, silibor, zixorin) caused an increase in the content of cytochromes P450 and b5 and in the activity of the main microsomal enzymes in the liver of rats with ARI. At the same time the survival of animals with ARI increased. The use of inductors and hepatic protectors as measures of pathogenetic therapy in disturbed detoxification function of the liver in ARI is promising.

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