The effect of hepatoprotectors on the functional activity of rat hepatocyte mitochondria in in-vitro and in-vivo systems
Gordienko, A.D.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(4): 18-19
1992
ISSN/ISBN: 0869-2092 PMID: 1458178 Document Number: 402852
In in vitro experiments essential, flacumin, and silibor inhibited the respiratory activity of isolated mitochondria and failed to affect the respiration of hepatocytes in rats at condition 4 by Chance. Essential uncoupled mitochondrial oxidative phosphorylation in the in vitro system. The hepatoprotectors used in ethanol-induced abnormality restored the activity of mitochondrial oxidative phosphorylation of hepatocytes to its level in intact animals.
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