Immunomodulators with an 8-azasteroid structure as inducers of liver cytochrome P-450
Kuz'mitskiĭ, B.B.; Dad'kov, I.G.; Mashkovich, A.E.; Stoma, O.V.; Slepneva, L.M.
Farmakologiia i Toksikologiia 53(2): 52-55
1990
ISSN/ISBN: 0014-8318 PMID: 2369956 Document Number: 351911
Two structural analogues of D-homo-8-azasteroids, both an immunostimulant and an immunodepressant, are inductors of the liver cytochrome P-450 in animals. This capability was shown by means of both a decrease of the hexenal sleep duration in the pharmacological test and an increase of the quantity of cytochrome P-450 and the rate of N-demethylation of aminopyrine in the biochemical assays.
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