3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats
Mizokami, K.; Inoue, K.; Sunouchi, M.; Fujimori, K.; Takanaka, A.; Omori, Y.
Biochemical and Biophysical Research Communications 107(1): 6-11
1982
ISSN/ISBN: 0006-291X PMID: 6889862 Document Number: 193598
The characteristic nature of the drug-metabolizing system in fetal liver microsomes of rats was investigated. The aminopyrine(AM)- and the hexobarbital (HB)-metabolizing activities in fetal liver microsomes of the 21st day of pregnancy were induced by the maternal administration of 3-methylcholanthrene (3-MC) once daily on the 18th and the 19th day of pregnancy, while they were inhibited in maternal liver microsomes. The inductions of the AM- and the HB-metabolizing enzymes n fetal liver microsomes of rat by the maternal administration of 3-MC occurred exclusively in fetal period, and simultaneously hemoprotein like phenobarbital-induced type P-450, different from that in maternal liver microsomes, was newly induced in fetal liver microsomes of rats.