Influence of delta-sleep-inducing peptide on the activity of proteolytic enzymes in the rat brain under hypokinesia
Mendzheritskiĭ, A.M.; Lysenko, A.V.; Mikhaleva, I.I.
Ukrainskii Biokhimicheskii Zhurnal 64(5): 37-42
1992
ISSN/ISBN: 0201-8470 PMID: 1462368 Document Number: 398068
Single administration of the delta-sleep-inducing peptide (DSIP) in a dose of 12 micrograms/100 g to intact animals makes the activity of neutral proteinases and cathepsin D higher in the rat brain and blood serum. Hypokinesia of different duration changes activity of neutral and acidic proteinases and induces accessibility of cathepsin D to the cytosol as a result of damage in lysosomal membrane. Injection DSIP induces a decrease A/B of cathepsin D to the control level under 1-h hypokinesia condition and normalizes the neutral proteolytic activity under 6-h hypokinesia condition.