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Activity of oxidative enzymes of the tricarboxylic acid cycle in rat myocardium in hypokinesia

Ganin, I.A.

Kardiologiia 23(9): 87-90

1983

ISSN/ISBN: 0022-9040
PMID: 6645199
Document Number: 212569
An experimental study in rats demonstrated that limited motor activity resulted in a drop of mitochondrial tricarboxylic dehydrogenase activity. Early dates of hypokinesia are characterized by a decrease in specific activity of dehydrogenases, and on days 45 and 60 the changes are due to smaller levels of mitochondrial fraction protein. The activity of cytoplasmic NADP-MDH and NAD-MDH undergoes changes by day 60 of immobilization, and that of NADP-ICDH by day 7 only. Hypokinesia disrupts the ratio between mitochondrial and cytoplasmic dehydrogenases. A twenty-five-day-long recovery period is not sufficient for the normalization of oxidative processes in the tricarboxylic acids cycle.

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