Optimal structure of the multienzyme system of the tricarboxylic acid cycle of E. coli during growth on various carbon sources
Drozdov-Tikhomirov, L.N.; Buzinier, M.A.; Vompe, A.G.; Skurida, G.I.
Biokhimiia 59(3): 368-380
1994
ISSN/ISBN: 0320-9725 PMID: 8180270 Document Number: 424440
The optimal structure (stoichiometry) of the tricarboxylic acid cycle multienzyme system of E. coli has been computed using experimental data for the E. coli biomass monomeric content and the results of the steady-state metabolic fluxes calculation. The calculation was performed for the cases of E. coli growth on acetate, glycolate, glycerate, glutamate, glucose, gluconate and pyruvate as carbon sources. The possible self-control mechanisms make it possible to optimize the cellular multienzyme system structure for each of the carbon sources under study. The relationship between the optimal structure and the maximal specific rate of the cell growth is discussed.