Morphometric evidence of activation of axo-somatic synapses during administration of delta sleep-inducing peptide
Mendzheritskiĭ, A.M.; Kuraev, G.A.; Mikhaleva, I.I.; Povilaĭtite, P.E.
Biulleten' Eksperimental'noi Biologii i Meditsiny 113(2): 202-203
1992
ISSN/ISBN: 0365-9615 PMID: 1611076 Document Number: 396152
Computed morphometry proved activation of neocortex layer III-V axosomatic synapses. This is evident from an increase in the mean plasmalemma length, that in the active synapse zones on neurone bodies and width of the synaptic cleft, this being induced by a single intraperitoneal administration of delta-sleep-inducing peptide. The activation of the axosomatic synapses correlates with elevated GABA levels in the cerebral hemispheres cortex.