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Activity of proteolytic enzymes and trypsin inhibitor in blood serum and kidney in pyelonephritis

Levitsky, A.P.; Grabazyuk

Voprosy Meditsinskoi Khimii 21(5): 538-542

1975

ISSN/ISBN: 0042-8809
PMID: 1216770
Document Number: 91287
In 116 patients with acute and chronic pyelonephritis and in 66 healthy persons the total proteolytic, trypsin-like, catheptic, BAEE-esterase activities and the content of trypsin inhibitor were determined in blood serum and kidney tissue. The total proteolytic and catheptic activities were distinctly increased in blood serum and, especially, in kidney tissue under acute pyelonephritis. In chronic pyelonephritis the activity of cathepsins was decreased in blood serum. The trypsin-like activity tended to decrease both in blood serum and kidney. The BAEE-esterase activity was increased in kidney, particularly in acute pyelonephritis, but in blood serum it was decreased. The inhibitor of trypsin was not found in kidney; in blood serum its content was slightly increased in acute pyelonephritis but there were only slight alterations in the chronic disease.

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