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Proteolytic enzymes and their inhibitors in the tumors and blood serum of patients with breast neoplasms

Blizniuk, B.F.

Voprosy Meditsinskoi Khimii 28(4): 123-126

1982

ISSN/ISBN: 0042-8809
PMID: 7051547
Document Number: 183492
Content of proteinases and trypsin inhibitor was studied in non-malignant and malignant tumors as well as in blood serum of 120 patients with mammary gland neoplasm. In malignant tumors activity of acid and casein-degrading proteinases was increased as compared with non-impaired tissue of mammary gland. Activity of proteolytic enzymes in non-malignant tumors corresponded to an intermediate value between the activity in malignant tumors and in non-impaired tissue. Content of the trypsin inhibitor was distinctly increased in non-malignant tumors and unaltered -- in malignant tissues. The inhibitor content was increased in blood serum of patients with metastases in lymphoid nodes. These data demonstrate the activation of proteolysis in malignant mammary gland and suggest a possible role of proteolytic enzymes in carcinogenesis.

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