Study of the complement system and the inhibitors of plasma proteolytic enzymes in the erythrocytes during blood preservation
Krizhevskaia, I.V.; Vavilova, L.M.; Kuz'micheva, M.Iu.; Markova, O.A.; Tibilova, N.N.; Ermol'chuk, O.N.
Gematologiia i Transfuziologiia 35(5): 18-21
1990
ISSN/ISBN: 0234-5730 PMID: 1697549 Document Number: 350548
Changes in the activity of the complement system components C1--C5, and proteinase inhibitors: alpha 1-inhibitor, alpha 2-macroglobulin and antithrombin III were studied in red blood cell pack during storage at 4 degrees C, in comparison with erythroconcentrate. A decrease, detected in the level of C1, C3 and alpha 2-macroglobulin, was more pronounced in the erythroconcentrate than in the red blood cell pack. The data obtained have evidenced that the adequate amount of plasma plays an important role in the red blood cell preservation and prevention of accumulation of undesirable physiologically active substances in the transfusion solutions.