Effect of anthelmintics on phosphatases in Ascaridia galli
Aggarwal, R.; Sanyal, S.N.; Khera, S.
Acta Veterinaria Hungarica 40(4): 243-249
1992
ISSN/ISBN: 0236-6290 PMID: 1339058 Document Number: 391035
In vitro addition of the drugs tetramisole (TMS) and levamisole (LMS) caused an inhibition of the specific activities of acid phosphatase and Mg(++)-dependent adenosine triphosphatase. The inhibition was non-competitive in nature. No significant inhibition was caused by TMS in the activity of glucose-6-phosphatase, but LMS inhibited the enzyme in a non-competitive manner. The activity of alkaline phosphatase was, however, increased in the presence of both TMS and LMS.