Dynamics of circulating antibodies against Trichinella spiralis after application of anthelmintics
Corba, J.; Cerman, J.; Spaldonová, R.
Folia Parasitologica 24(2): 135-139
1977
ISSN/ISBN: 0015-5683 PMID: 881141 Document Number: 110945
Formation and dynamics of circulating antibodies were studied using the latex-fixation tube test in mice experimentally infected with T. spiralis and treated with mebendazole. In the control group of untreated mice antibodies were detected on the 21st day after infection. The antibody level reached the maximum on day 76 and low titers were found on day 207 after infection. In mice treated with mebendazole in the intestinal phase of trichinellosis, the antibodies were detected 10 or 7 days earlier than in the control group. At this time antibody level reached a maximum and then decreased gradually until no antibodies were detected on days 66-76. This phenomenon correlated with postmortem examination and suggested that the formation and dynamics of circulating antibodies against T. spiralis were directly dependent on the effectiveness of the treatment.