Effect of anthelmintics and phenothiazines on adenosine 5'-triphosphatases of filarial parasite Setaria cervi

Agarwal, A.; Tekwani, B.L.; Shukla, O.P.; Ghatak, S.

Indian Journal of Experimental Biology 28(3): 245-248

1990


ISSN/ISBN: 0019-5189
PMID: 2163977
Document Number: 154
S. cervi showed particulate Ca2+ ATPase and Na+, K+-ATPase activities while Mg2+ ATPase was detected in traces. ATPase of S. cervi was also differentiated from the nonspecific p-nitrophenyl phosphatase activity. Female parasite and microfilariae exhibited higher Ca2+ ATpase and Na+, K+-ATPase activities than the male adults and the enzyme Na+, K+-ATPase wa mainly concentrated in the gastrointestinal tract of the filarial parasite Na+, K+-ATPase of the filariid was ouabain-sensitive while Ca2+-ATPase activity was regulated by concentration of Ca2+ ions and inhibited by EGTA. Phenothiazines, viz. trifuoperazine, promethazine and chlorpromaizine caused significant inhibition of Ca2+ ATPase and Na+, K+-ATPase. Diethylcarbamazine was a potent inhibitor of these ATPases. Mebendazole, levamisole and centperazine also caused significant inhibition of the ATPases indicating this enzyme system as a common target for the action of anthelmintic drugs.

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Effect of anthelmintics and phenothiazines on adenosine 5'-triphosphatases of filarial parasite Setaria cervi