Protective property of azelastine against histamine challenge of rhinal mucosa in domestic pigs
Stroman, F.; Herold, H.; Szelenyi, I.
Arzneimittel-Forschung 41(10): 1092-1094
1991
ISSN/ISBN: 0004-4172 PMID: 1686828 Document Number: 378083
In anaesthetized domestic pigs a filter paper sampling technique was applied to estimate basal and histamine induced nasal secretion. Histamine (0.2 mg/nostril) increased secretion more than twofold, a dose of 2 mg/nostril more than 10 fold. Intranasally instilled azelastine (A-5610, CAS 58581-89-8) prevented this histamine induced rhinorrhea without reduction of basal secretion. The protective effect remained for more than 2 h even when histamine challenge was repeated.