Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs
Hu, H.J.; Dai, D.Z.; Shen, Y.M.
Zhongguo Yao Li Xue Bao 18(2): 159-160
1997
ISSN/ISBN: 0253-9756 PMID: 10072971 Document Number: 483193
AIM: To study effects of histamine on cardiomyopathy. METHODS: Cardiomyopathy model was developed in guinea pig by ip levothyroxine 0.5 mg cntdot kg-1 cntdot d-1 for 10 d. Langendroff's hearts were perfused. ECG and contractile force were recorded. Histamine (5 mu-g) was given by intraaortic injection. Histamine content of venous effluent was determined fluorometrically. RESULTS: Attack of histamine on cardiomyopathy was severer than that in normal hearts. Tachycardia was more prominent; atrioventricular conduction block occurred earlier; decrease in coronary flow was more marked. Uptakes of histamine were 37% in the model and 19% in the normal hearts (P lt 0.01). CONCLUSION: Histamine aggravated levothyroxine-cardiomyopathy.