Histamine-release in rat gastric mucosa by pentagastrin
Subramanian, N.; Mitznegg, P.; Domschke, W.; Domschke, S.; Faschingbauer, C.
Acta Hepato-Gastroenterologica 26(2): 133-135
1979
ISSN/ISBN: 0300-970X PMID: 88860 Document Number: 140441
The release of histamine from isolated gastric mucosa of the rat was studied by a superfusion model. Pentagastrin increased the basal efflux of histamine in a dose dependent manner. Secretin failed to influence the release of histamine under similar conditions. The results are compatible with the view that in gastric mucosa pentagastrin releases histamine which then may react with the receptors of the parietal cell thus serving as mediator in the acid secretory process.
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