Gastroprotective effects of histamine H2-receptor blockers in Helicobacter-like gastric mucosa lesions
Spasov, A.A.; Chernikov, M.V.; Speranskaia, A.S.; Zaĭchenko, S.I.
Eksperimental'naia i Klinicheskaia Gastroenterologiia 6: 24-27; 111-112
2005
ISSN/ISBN: 1682-8658 PMID: 17378382 Document Number: 587280
This study was designed as a comparative experimental analysis of the gastroprotective effects of two H2-blocking agents--famotidine and benzimidazole compound 64--on the model rat stomach Helicobacter-like mucous lesions. Both substances demonstrated dose-dependent gastroprotective effects both on the macro- and microscopic levels. ED50 made up 21.8 mg/kg and 13.5 mg/kg, respectively.
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