Inhibition by azelastine of the immunologically induced histamine release from isolated guinea pig mast cells
Fischer, B.; Schmutzler, W.
Arzneimittel-Forschung 31(8): 1193-1195
1981
ISSN/ISBN: 0004-4172 PMID: 6170297 Document Number: 174383
4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone (azelastine, A 5610) did not affect the spontaneous histamine release but inhibited effectively the allergic histamine release from isolated mesenteric mast cells of actively sensitized guinea pigs. At 10(-6) mol/l concentration the inhibition was almost equal to that caused by adrenaline (10(-8) mol/l).
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